Ingrid Derks

2024

Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies

Montironi, C., Chen, Z., Derks, I. A. M., Cretenet, G., Krap, E. A., Eldering, E. & Simon-Molas, H., 17 May 2024, In: iScience. 27, 5, p. 109640

Research output: Contribution to journal › Article › Academic › peer-review

2023

Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies

Favaro, F., Both, D., Derks, I. A. M., Spaargaren, M., Muñoz-Pinedo, C. & Eldering, E., 1 Dec 2023, In: Oncogenesis. 12, 1, 6.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

1 Citation (Scopus)

2022

SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

Leeksma, A. C., Derks, I. A. M., Garrick, B., Jongejan, A., Colombo, M., Bloedjes, T., Trowe, T., Leisten, J. C., Howarth, M., Malek, M., Mortensen, D. S., Blease, K., Groza, M. C., Narla, R. K., Loos, R., Kersten, M-J., Moerland, P. D., Guikema, J. E. J., Kater, A. P., Eldering, E., & 1 othersFilvaroff, E. H., 18 Nov 2022, (E-pub ahead of print) In: Molecular Oncology.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

1 Citation (Scopus)

2021

The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Leeksma, A. C., Derks, I. A. M., Kasem, M. H., Kilic, E., de Klein, A., Jager, M. J., van de Loosdrecht, A. A., Jansen, J. H., Navrkalova, V., Faber, L. M., Zaborsky, N., Egle, A., Zenz, T., Pospisilova, S., Abdel-Wahab, O., Kater, A. P. & Eldering, E., 29 Jan 2021, In: Frontiers in Oncology. 10, 609409.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

13 Citations (Scopus)

2020

CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells

Martens, A. W. J., Janssen, S. R., Derks, I. A. M., Adams Iii, H. C., Izhak, L., van Kampen, R., Tonino, S. H., Eldering, E., van der Windt, G. J. W. & Kater, A. P., 1 Jun 2020, In: Journal for Immunotherapy of Cancer. 8, 1

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

18 Citations (Scopus)

2016

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia

Thijssen, R., ter Burg, J., Garrick, B., van Bochove, G. G. W., Brown, J. R., Fernandes, S. M., Rodríguez, M. S., Michot, J-M., Hallek, M., Eichhorst, B., Reinhardt, H. C., Bendell, J., Derks, I. A. M., van Kampen, R. J. W., Hege, K., Kersten, M. J., Trowe, T., Filvaroff, E. H., Eldering, E. & Kater, A. P., 2016, In: Blood. 128, 4, p. 574-583

Research output: Contribution to journal › Article › Academic › peer-review

62 Citations (Scopus)

2015

Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification

te Raa, G. D., Moerland, P. D., Leeksma, A. C., Derks, I. A., Yigittop, H., Laddach, N., Loden-van Straaten, M., Navrkalova, V., Trbusek, M., Luijks, D. M., Zenz, T., Skowronska, A., Hoogendoorn, M., Stankovic, T., van Oers, M. H., Eldering, E. & Kater, A. P., 2015, In: Cell Death & Disease. 6, p. e1852

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

Vieira Braga, F. A., Hertoghs, K. M. L., Kragten, N. A. M., Doody, G. M., Barnes, N. A., Remmerswaal, E. B. M., Hsiao, C-C., Moerland, P. D., Wouters, D., Derks, I. A. M., van Stijn, A., Demkes, M., Hamann, J., Eldering, E., Nolte, M. A., Tooze, R. M., ten Berge, I. J. M., van Gisbergen, K. P. J. M. & van Lier, R. A. W., 2015, In: European journal of immunology. 45, 10, p. 2945-2958

Research output: Contribution to journal › Article › Academic › peer-review

87 Citations (Scopus)

Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia

Tonino, S. H., Mulkens, C. E., van Laar, J., Derks, I. A. M., Suo, G., Croon-de Boer, F., van Oers, M. H. J., Eldering, E., Wang, J. Y. & Kater, A. P., 2015, In: Leukemia & lymphoma. 56, 8, p. 2439-2447

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

The impact of SF3B1 mutations in CLL on the DNA-damage response

te Raa, G. D., Derks, I. A. M., Navrkalova, V., Skowronska, A., Moerland, P. D., van Laar, J., Oldreive, C., Monsuur, H., Trbusek, M., Malcikova, J., Lodén, M., Geisler, C. H., Hüllein, J., Jethwa, A., Zenz, T., Pospisilova, S., Stankovic, T., van Oers, M. H. J., Kater, A. P. & Eldering, E., 2015, In: Leukemia. 29, 5, p. 1133-1142

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

2013

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

Wensveen, F. M., Geest, C. R., Libregts, S. F. W. M., Derks, I. A. M., Ekert, P. G., Labi, V., Villunger, A., Nolte, M. A. & Eldering, E., 2013, In: Apoptosis. 18, 11, p. 1306-1318

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

Pascutti, M. F., Jak, M., Tromp, J. M., Derks, I. A. M., Remmerswaal, E. B. M., Thijssen, R., van Attekum, M. H. A., van Bochove, G. G., Luijks, D. M., Pals, S. T., van Lier, R. A. W., Kater, A. P., van Oers, M. H. J. & Eldering, E., 2013, In: Blood. 122, 17, p. 3010-3019

Research output: Contribution to journal › Article › Academic › peer-review

96 Citations (Scopus)

Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology

Wensveen, F. M., Klarenbeek, P. L., van Gisbergen, K. P. J. M., Pascutti, M. F., Derks, I. A. M., van Schaik, B. D. C., ten Brinke, A., de Vries, N., Cekinovic, D., Jonjic, S., van Lier, R. A. W. & Eldering, E., 2013, In: Journal of immunology (Baltimore, Md.. 190, 3, p. 1180-1191

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

2012

BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation

Wensveen, F. M., Derks, I. A. M., van Gisbergen, K. P. J. M., de Bruin, A. M., Meijers, J. C. M., Yigittop, H., Nolte, M. A., Eldering, E. & van Lier, R. A. W., 2012, In: Blood. 119, 6, p. 1440-1449

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load

Wensveen, F. M., Unger, P-P. A., Kragten, N. A. M., Derks, I. A. M., ten Brinke, A., Arens, R., van Lier, R. A. W., Eldering, E. & van Gisbergen, K. P. J. M., 2012, In: Journal of immunology (Baltimore, Md.. 188, 9, p. 4256-4267

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Notch controls the magnitude of T helper cell responses by promoting cellular longevity

Helbig, C., Gentek, R., Backer, R. A., de Souza, Y., Derks, I. A. M., Eldering, E., Wagner, K., Jankovic, D., Gridley, T., Moerland, P. D., Flavell, R. A. & Amsen, D., 2012, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109, 23, p. 9041-9046

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

2011

A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity

Kuijpers, T. W., Baars, P. A., Aan de Kerk, D. J., Jansen, M. H., Derks, I. A. M., Bredius, R. G. M., Sanders, E. A. M., van der Burg, M., Alders, M. & van Lier, R. A. W., 2011, In: Journal of allergy and clinical immunology. 128, 6, p. 1360-1363.e4

Research output: Contribution to journal › Comment/Letter to the editor › Academic

8 Citations (Scopus)

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

Wensveen, F. M., Alves, N. L., Derks, I. A. M., Reedquist, K. A. & Eldering, E., 2011, In: Apoptosis. 16, 7, p. 708-721

Research output: Contribution to journal › Article › Academic › peer-review

53 Citations (Scopus)

2010

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

Wensveen, F. M., van Gisbergen, K. P. J. M., Derks, I. A. M., Gerlach, C., Schumacher, T. N., van Lier, R. A. W. & Eldering, E., 2010, In: Immunity. 32, 6, p. 754-765

Research output: Contribution to journal › Article › Academic › peer-review

75 Citations (Scopus)

CD20 deficiency in humans results in impaired T cell-independent antibody responses

Kuijpers, T. W., Bende, R. J., Baars, P. A., Grummels, A., Derks, I. A. M., Dolman, K. M., Beaumont, T., Tedder, T. F., van Noesel, C. J. M., Eldering, E. & van Lier, R. A. W., 2010, In: The journal of clinical investigation. 120, 1, p. 214-222

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

293 Citations (Scopus)

2008

Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling

Alves, N. L., van Leeuwen, E. M. M., Derks, I. A. M. & van Lier, R. A. W., 2008, In: Journal of immunology (Baltimore, Md.. 180, 8, p. 5201-5210

Research output: Contribution to journal › Article › Academic › peer-review

73 Citations (Scopus)

2007

Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection

Hallaert, D. Y. H., Spijker, R., Jak, M., Derks, I. A. M., Alves, N. L., Wensveen, F. M., de Boer, J. P., de Jong, D., Green, S. R., van Oers, M. H. J. & Eldering, E., 2007, In: Cell death and differentiation. 14, 11, p. 1958-1967

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

2006