Medical Biochemistry

Research output

Research output per year 1988 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 981 Article
• 120 Review article
• 42 Editorial
• 36 Comment/Letter to the editor
• 66 More
  • 26 Chapter
  • 21 Phd-Thesis - Research and graduation internal
  • 7 Erratum/Corrigendum
  • 3 Other contribution
  • 3 Phd-Thesis - Research and graduation external
  • 2 Letter
  • 1 Book editing
  • 1 Conference contribution
  • 1 Abstract
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Genetic Factors Altering Immune Responses in Atrial Fibrillation: JACC Review Topic of the Week

  Ninni, S., Dombrowicz, D., de Winther, M., Staels, B., Montaigne, D. & Nattel, S., 26 Mar 2024, In: Journal of the American College of Cardiology. 83, 12, p. 1163-1176 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

• Mitochondrial genomes revisited: why do different lineages retain different genes?

  Butenko, A., Lukeš, J., Speijer, D. & Wideman, J. G., 1 Dec 2024, In: BMC Biology. 22, 1, 15.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Tumour-infiltrating lymphocyte therapy for patients with advanced-stage melanoma

  Klobuch, S., Seijkens, T. T. P., Schumacher, T. N. & Haanen, J. B. A. G., Mar 2024, In: Nature reviews. Clinical oncology. 21, 3, p. 173-184 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
• 2023

  A new SPRING in lipid metabolism

  Hendrix, S. & Zelcer, N., 1 Oct 2023, In: Current opinion in lipidology. 34, 5, p. 201-207 7 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling

  van der Krogt, J. M. A., van der Meulen, I. J. E. & van Buul, J. D., 1 Aug 2023, In: Current Opinion in Physiology. 34, 100676.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• The emerging role for CAR T cells in solid tumor oncology

  Klobuch, S., Seijkens, T. T. P. & Haanen, J. B. A. G., 1 Apr 2023, In: Chinese clinical oncology. 12, 2, p. 19 19.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• The regulatory landscape of macrophage interferon signaling in inflammation

  Siebeler, R., de Winther, M. P. J. & Hoeksema, M. A., 1 Aug 2023, In: Journal of allergy and clinical immunology. 152, 2, p. 326-337 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• The ubiquitous role of ubiquitination in lipid metabolism

  Loix, M., Zelcer, N., Bogie, J. F. J. & Hendriks, J. J. A., 2023, (E-pub ahead of print) In: Trends in Cell Biology.

  Research output: Contribution to journal › Review article › Academic › peer-review
  2 Citations (Scopus)

• Translational opportunities of single-cell biology in atherosclerosis

  de Winther, M. P. J., Bäck, M., Evans, P., Gomez, D., Goncalves, I., Jørgensen, H. F., Koenen, R. R., Lutgens, E., Norata, G. D., Osto, E., Dib, L., Simons, M., Stellos, K., Ylä-Herttuala, S., Winkels, H., Bochaton-Piallat, M-L. & Monaco, C., 7 Apr 2023, In: European Heart journal. 44, 14, p. 1216-1230 15 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  23 Citations (Scopus)

• Trypanosomes as a magnifying glass for cell and molecular biology

  Lukeš, J., Speijer, D., Zíková, A., Alfonzo, J. D., Hashimi, H. & Field, M. C., Nov 2023, In: Trends in parasitology. 39, 11, p. 902-912 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  5 Citations (Scopus)
• 2022

  Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart

  van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B. J. J. M., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., Giacca, M., & 41 othersGirao, H., Gollmann-Tepeköylü, C., Gyongyosi, M., Guzik, T. J., Hamdani, N., Heymans, S., Hilfiker, A., Hilfiker-Kleiner, D., Hoekstra, A. G., Hulot, J-S., Kuster, D. W. D., van Laake, L. W., Lecour, S., Leiner, T., Linke, W. A., Lumens, J., Lutgens, E., Madonna, R., Maegdefessel, L., Mayr, M., van der Meer, P., Passier, R., Perbellini, F., Perrino, C., Pesce, M., Priori, S., Remme, C. A., Rosenhahn, B., Schotten, U., Schulz, R., Sipido, K. R., Sluijter, J. P. G., van Steenbeek, F., Steffens, S., Terracciano, C. M., Tocchetti, C. G., Vlasman, P., Yeung, K. K., Zacchigna, S., Zwaagman, D. & Thum, T., Nov 2022, In: Cardiovascular research. 118, 15, p. 3016-3051 36 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  28 Citations (Scopus)

• Macrophages in Lupus Nephritis: Exploring a potential new therapeutic avenue

  Kwant, L. E., Vegting, Y., Tsang-a-Sjoe, M. W. P., Kwakernaak, A. J., Vogt, L., Voskuyl, A. E., van Vollenhoven, R. F., de Winther, M. P. J., Bemelman, F. J., Anders, H-J. & Hilhorst, M. L., 1 Dec 2022, In: Autoimmunity Reviews. 21, 12, 103211.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

  Ruffilli, C., Roth, S., Rodrigo, M., Boyd, H., Zelcer, N. & Moreau, K., 14 Oct 2022, In: ACS Pharmacology and Translational Science. 5, 10, p. 849-858 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Regulating trained immunity with nanomedicine

  van Leent, M. M. T., Priem, B., Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Zwolsman, R., Beldman, T. J., Netea, M. G. & Mulder, W. J. M., Jun 2022, In: Nature Reviews Materials. 7, 6, p. 465-481 17 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  41 Citations (Scopus)

• Vascular stiffening and endothelial dysfunction in atherosclerosis

  Hooglugt, A., Klatt, O. & Huveneers, S., 1 Dec 2022, In: Current opinion in lipidology. 33, 6, p. 353-363 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  13 Citations (Scopus)
• 2021

  Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

  Hooglugt, A., van der Stoel, M. M., Boon, R. A. & Huveneers, S., 4 Feb 2021, In: Frontiers in Oncology. 10, 612802.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis

  Bosmans, L. A., Shami, A., Atzler, D., Weber, C., Gonçalves, I. & Lutgens, E., Aug 2021, In: Vascular Pharmacology. 139, 106884.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• How (Epi)genetic regulation of the LIM-domain protein FHL2 impacts multifactorial disease

  Habibe, J. J., Clemente-Olivo, M. P. & de Vries, C. J., 1 Oct 2021, In: Cells. 10, 10, 2611.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: An emerging clinical problem

  Poels, K., Neppelenbroek, S. I. M., Kersten, M. J., Antoni, M. L., Lutgens, E. & Seijkens, T. T. P., 24 Jun 2021, In: Journal for Immunotherapy of Cancer. 9, 6, e002916.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  31 Citations (Scopus)

• Is There a Carcinogenic Risk Attached to Vitamin B₁₂ Deficient Diets and What Should We Do About It? Reviewing the Facts

  Loedin, A. K. & Speijer, D., Mar 2021, In: Molecular Nutrition and Food Research. 65, 6, 2000945.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Monocytes and macrophages in ANCA-associated vasculitis

  Vegting, Y., Vogt, L., Anders, H-J., de Winther, M. P. J., Bemelman, F. J. & Hilhorst, M. L., 1 Oct 2021, In: Autoimmunity Reviews. 20, 10, 102911.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  33 Citations (Scopus)

• Nanoengineering Apolipoprotein A1-Based Immunotherapeutics

  Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Kluza, E., Zwolsman, R., Deckers, J., Anbergen, T., de Bruin, K., Trines, M. M., Nugraha, E. G., Ummels, F., Röring, R. J., Beldman, T. J., Teunissen, A. J. P., Fayad, Z. A., van der Meel, R. & Mulder, W. J. M., Aug 2021, In: Advanced Therapeutics. 4, 8, 2100083.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Nuclear receptor Nur77: Its role in chronic inflammatory diseases

  Lith, S. C. & de Vries, C. J. M., 1 Nov 2021, In: Essays in biochemistry. 65, 6, p. 927-939 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  20 Citations (Scopus)

• Selective targeting of epigenetic readers and histone deacetylases in autoimmune and inflammatory diseases: Recent advances and future perspectives

  Ghiboub, M., Elfiky, A. M. I., de Winther, M. P. J., Harker, N. R., Tough, D. F. & de Jonge, W. J., 1 May 2021, In: Journal of Personalized Medicine. 11, 5, 336.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• Six shades of vascular smooth muscle cells illuminated by klf4 (krüppel-like factor 4)

  Yap, C., Mieremet, A., de Vries, C. J. M., Micha, D. & de Waard, V., 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 11, p. 2693-2707 15 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  100 Citations (Scopus)

• Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies

  Lutgens, E., Joffre, J., van Os, B. & Ait-Oufella, H., 1 Oct 2021, In: Atherosclerosis. 335, p. 98-109 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  8 Citations (Scopus)

• The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

  Bosmans, L. A., Bosch, L., Kusters, P. J. H., Lutgens, E. & Seijkens, T. T. P., Feb 2021, In: Journal of cardiovascular translational research. 14, 1, p. 13-22 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  33 Citations (Scopus)

• The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis

  Verberk, S. G. S., Kuiper, K. L., Lauterbach, M. A., Latz, E. & van den Bossche, J., Dec 2021, In: Trends in molecular medicine. 27, 12, p. 1095-1105 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  16 Citations (Scopus)

• Unconventional interleukin-1β release suppresses antitumor immunity

  van den Bossche, J., 20 Jan 2021, In: Science Translational Medicine. 13, 577, eabg4726.

  Research output: Contribution to journal › Review article › Academic › peer-review
  1 Citation (Scopus)
• 2020

  Cell-cell junctions as sensors and transducers of mechanical forces

  Angulo-Urarte, A., van der Wal, T. & Huveneers, S., 1 Sept 2020, In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1862, 9, 183316.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  85 Citations (Scopus)

• Defining trained immunity and its role in health and disease

  Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J. & Latz, E., 1 Jun 2020, In: Nature Reviews. Immunology. 20, 6, p. 375-388 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  1241 Citations (Scopus)

• E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease

  Poels, K., Vos, W. G., Lutgens, E. & Seijkens, T. T. P., 5 Jun 2020, In: Frontiers in cardiovascular medicine. 7, 106.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Macrophage subsets in atherosclerosis as defined by single-cell technologies

  Willemsen, L. & de Winther, M. P. J., 1 Apr 2020, In: Journal of pathology. 250, 5, p. 705-714 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  120 Citations (Scopus)

• Nuclear imaging approaches facilitating nanomedicine translation

  Pérez-Medina, C., Teunissen, A. J. P., Kluza, E., Mulder, W. J. M. & van der Meel, R., Jan 2020, In: Advanced drug delivery reviews. 154-155, p. 123-141 19 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  40 Citations (Scopus)

• Transcriptional and epigenetic regulation of macrophages in atherosclerosis

  Kuznetsova, T., Prange, K. H. M., Glass, C. K. & de Winther, M. P. J., 1 Apr 2020, In: Nature Reviews. Cardiology. 17, 4, p. 216-228 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  173 Citations (Scopus)

• Type-I interferons in atherosclerosis

  Chen, H-J., Tas, S. W. & de Winther, M. P. J., 1 Jan 2020, In: Journal of Experimental Medicine. 217, 1, e20190459.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  53 Citations (Scopus)

• Why vessels do not leak when leukocytes migrate out

  van Buul, J. D., 30 Jul 2020, In: Blood. 136, 5, p. 531-532 2 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

• ‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity

  Lith, S. C., van Os, B. W., Seijkens, T. T. P. & de Vries, C. J. M., 1 Nov 2020, In: European journal of immunology. 50, 11, p. 1643-1652 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  18 Citations (Scopus)
• 2019

  Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo

  Chen, H-J., Li Yim, A. Y. F., Griffith, G. R., de Jonge, W. J., Mannens, M. M. A. M., Ferrero, E., Henneman, P. & de Winther, M. P. J., 2019, In: Frontiers in immunology. 10, 2887.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  28 Citations (Scopus)

• Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

  van Beek, A. A., van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J. & Leenen, P. J. M., 1 Feb 2019, In: Trends in immunology. 40, 2, p. 113-127 15 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  121 Citations (Scopus)

• Nature and nurture of tissue-specific macrophage phenotypes

  Hoeksema, M. A. & Glass, C. K., Feb 2019, In: Atherosclerosis. 281, p. 159-167 9 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• The potential beneficial effects of resveratrol on cardiovascular complications in marfan syndrome patients–insights from rodent-based animal studies

  van Andel, M. M., Groenink, M., Zwinderman, A. H., Mulder, B. J. M. & de Waard, V., 1 Mar 2019, In: International journal of molecular sciences. 20, 5, 1122.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  19 Citations (Scopus)

• Therapeutic targeting of trained immunity

  Mulder, W. J. M., Ochando, J., Joosten, L. A. B., Fayad, Z. A. & Netea, M. G., Jul 2019, In: Nature reviews. Drug discovery. 18, 7, p. 553-566 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  262 Citations (Scopus)
• 2018

  Future directions for therapeutic strategies in post-ischaemic vascularization: A position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

  Caporali, A., Bäck, M., Daemen, M. J., Hoefer, I. E., Jones, E. A., Lutgens, E., Matter, C. M., Bochaton-Piallat, M-L., Siekmann, A. F., Sluimer, J. C., Steffens, S., Tuñón, J., Vindis, C., Wentzel, J. J., Ylä-Herttuala, S. & Evans, P. C., 2018, In: Cardiovascular research. 114, 11, p. 1411-1421

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• High-Density Lipoprotein Nanobiologics for Precision Medicine

  Mulder, W. J. M., van Leent, M. M. T., Lameijer, M., Fisher, E. A., Fayad, Z. A. & Pérez-Medina, C., 2018, In: Accounts of chemical research. 51, 1, p. 127-137

  Research output: Contribution to journal › Review article › Academic › peer-review
  55 Citations (Scopus)

• How oxygen gave rise to eukaryotic sex

  Hörandl, E. & Speijer, D., 14 Feb 2018, In: Proceedings of the Royal Society B: Biological Sciences. 285, 1872, 20172706.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  40 Citations (Scopus)

• Investigating supramolecular systems using Förster resonance energy transfer

  Teunissen, A. J. P., Pérez-Medina, C., Meijerink, A. & Mulder, W. J. M., 2018, In: Chemical Society reviews. 47, 18, p. 7027-7044

  Research output: Contribution to journal › Review article › Academic › peer-review
  117 Citations (Scopus)

• Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases

  Hoogeveen, R. M., Nahrendorf, M., Riksen, N. P., Netea, M. G., de Winther, M. P. J., Lutgens, E., Nordestgaard, B. R. G., Neidhart, M., Stroes, E. S. G., Catapano, A. L. & Bekkering, S., 2018, In: European Heart journal. 39, 38, p. 3521-3527

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  43 Citations (Scopus)

• Regulating the human HECT E3 ligases

  Sluimer, J. & Distel, B., 2018, In: Cellular and molecular life sciences. 75, 17, p. 3121-3141

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  104 Citations (Scopus)
• 2017

  Applying nanomedicine in maladaptive inflammation and angiogenesis

  Alaarg, A., Pérez-Medina, C., Metselaar, J. M., Nahrendorf, M., Fayad, Z. A., Storm, G. & Mulder, W. J. M., 2017, In: Advanced drug delivery reviews. 119, p. 143-158

  Research output: Contribution to journal › Review article › Academic › peer-review
  42 Citations (Scopus)